CIPHER PHARMACEUTICALS INC. NOTICE OF ANNUAL GENERAL MEETING OF SHAREHOLDERS TO BE HELD ON JUNE 18, 2026

NOTICE IS HEREBY GIVEN that the Annual General Meeting (the “ Meeting ”) of the holders of common shares of Cipher Pharmaceuticals Inc. (“ Cipher ” or the “ Corporation ”) will be held on June 18, 2026 at 10:00 a.m. (Toronto time) at the offices of Fogler, Rubinoff LLP, 40 King Street West, Suite 2400, Toronto, Ontario, for the following purposes:

• (a) to receive and consider the consolidated financial statements of the Corporation for the year ended December 31, 2025, together with the report of the auditor thereon;

• (b) to elect directors for the ensuing year;

• (c) to re-appoint RSM Canada LLP as auditor for the ensuing year and to authorize the directors to fix the auditor’s remuneration; and

• (d) to transact such other business as may properly come before the Meeting or any adjournments or postponements thereof.

Only holders (“ Shareholders ”) of record at the close of business on May 11, 2026 (the “ Record Date ”) of common shares of the Corporation are entitled to notice of and to attend the Meeting or any adjournments or postponements thereof and to vote thereat.

Shareholders may vote in person at the Meeting or any adjournments or postponements thereof, or they may appoint another person (who need not be a Shareholder) as their proxy to attend and vote in their place.

Shareholders unable to attend the Meeting are requested to date and sign the enclosed form of proxy and return it to Computershare Investor Services Inc., attention: Proxy Department, 100 University Ave., 8^th Floor, Toronto, Ontario, M5J 2Y1 not later than 10:00 a.m. (Toronto time) on June 16, 2026, or, if the Meeting is adjourned or postponed, not less than 48 hours, excluding Saturdays, Sundays and statutory holidays in Toronto, Ontario, preceding the time of such adjourned or postponed Meeting. Voting can also be done by phone or internet as described in the accompanying Management Information Circular.

A Management Information Circular relating to the business to be conducted at the Meeting and, if previously requested, the Corporation’s 2025 Annual Report containing the audited consolidated financial statements of the Corporation for the financial year ended December 31, 2025, accompany this Notice.

DATED at Toronto, Ontario this 11^th day of May, 2026.

BY ORDER OF THE BOARD OF DIRECTORS

“ Craig Mull” (signed)

Interim Chief Executive Officer