AMGEN INC — Call Transcript 2026

Care Conference. I'm Tazeen Ahmad. I'm one of the senior biotech analysts here at the bank. It's my pleasure to have our next presenting company, Amgen. Sitting up on stage are several members from the Amgen team. Thanks in advance for making the trip over from California. We really appreciate it. We have Peter Griffith, who is Executive Vice President and CFO. We have Jay Bradner, who's Executive President of Research and Development. We of course have Casey Capparelli, who is Vice President, Investor Relations. Gentlemen, thank you for making the trip again. Thank you for having us. Okay. Maybe we could do a quick overview of the company and, some important, comments that you or statements that you need to make before we go into more detail. I'll turn it over to Peter for that. Great, Tazeen. Thank you. Good morning, everyone. I would just add, coming over to Las Vegas, there's traffic coming over, but in today's world, there's a lot less going back. Okay. So, uh, we'll take- It'll be a quick trip home. We'll take advantage of that. Thank you for having us. We are glad to be here. I've got a few prepared remarks I just want to run through and cover before we go to Q&A. We believe, first of all, there are a lot of ways for us to win, and look forward to the discussion around that, and especially winning for patients. We're pleased with the strong first quarter performance, which reinforces 2026 as a springboard year for Amgen. This is a year in which we expect the rapidly growing products we have to offset the impact of the patent expirations and increase competition. In the first quarter, we did exactly that. Revenue was up 6% year-over-year. Product sales were up 4% year-over-year. Non-GAAP earnings per share was up 5% year-over-year. Strong financial discipline exercise by the company. We've got significant breadth and depth across the portfolio. 16 products delivered double-digit or better sales growth in the first quarter year-over-year. 17 products annualizing at $1 billion or more in the first quarter based on first quarter sales. Importantly, our six key growth drivers, Repatha, Evenity, Tezspire, and then our innovative oncology, rare disease, and biosimilars portfolios accounted for nearly 70% of our product sales in the first quarter, and they grew at 24%, an aggregate rate of 24% growth on those six growth driver categories in the first quarter. Repatha, Evenity, and Tezspire each hold leadership positions in under-penetrated disease areas where there are millions of patients yet to be treated. These medicines all grew at 20% or more in the quarter and are well-positioned for continued growth this year and through the decade. Our rare disease portfolio grew 25% year-over-year. We see significant opportunities ahead as we scale those therapies and this category by reaching additional patients, expanding into new indications, and launching into new geographies. UPLIZNA exemplifies this opportunity. It's experiencing continued growth across multiple B-cell-mediated autoimmune diseases. Pretty good for CFO Jay. Pretty good. Pretty good. In Innovative oncology, our portfolio grew 25% year-over-year, driven by our bispecific T-cell engager portfolio or BiTE medicines, which are expanding what is possible for patients across multiple cancers. We remain particularly encouraged by IMDELLTRA, which is rapidly becoming a standard of care in late-line small cell lung cancer. Our biosimilars portfolio remains strong, driven by sales of PAVBLU this year. It's generated sales in excess of $14 billion cumulatively since we launched them in 2018. The portfolio is an important contributor to our growth, as well-positioned as the next wave of biosimilar candidates advances through phase III development. Let's turn to the pipeline. Our confidence continues to build in MariTide as a differentiated treatment for obesity, type 2 diabetes, and obesity-related conditions. We're executing effectively across the enterprise from clinical development to manufacturing as we advance MariTide's broad phase III program and build and optimize our manufacturing capacity ahead of launch. We expect MariTide to be important for weight loss induction, long-term weight maintenance, and for patients switching from weekly GLP-1 therapies to MariTide. With the potential for as few as four or six injections per year, our approach reflects how obesity care may evolve. Patients need effective initial weight loss and practical, durable maintenance options. Beyond MariTide, we see strong potential across a number of other programs in late-stage development, including olpasiran, our Lp-lowering medicine in phase III development, dazodalibep in phase III for Sjögren's disease, and xaluritamig, which is in phase III for late-stage prostate cancer. On the tax front, there are two related matters with the same core issue, value attribution. The IRS is arguing that our Puerto Rico operations should be treated as if they were essentially a limited value contract manufacturer. We strongly disagree with that position. We've got 2,500 plus colleagues who are United States citizens there, the majority with technical degrees. It's a very complex operation. There are two tax periods in question, 2010-2015 and 2016-2018. The 2010 through 2015 tax court matter is not new. There have been no changes in our position on the status of that case. It's been fully tried and litigated. We remain highly confident in the case we presented at trial, and we continue to expect a decision no earlier than the second half of 2026. As expected in the ordinary course of the IRS audit process, we received a draft notice of proposed adjustment, what I call a NOPA, in April, for similar transfer pricing issues for the 2016-2018 period. It's just an early step in what we would expect to be a multi-year process. It's not a final determination. Importantly, our commitment to Puerto Rico continues to grow. Since our first quarter call, we announced an additional $300 million in investment, building on the previously announced $650 million in our Puerto Rico facility. Puerto Rico is a core part of Amgen's U.S. manufacturing network, with advanced manufacturing capabilities for biologics, deep expertise all the way around. We strongly disagree with any characterization of these operations as limited value contract manufacturing. We continue to believe the IRS claims are without merit and our reserves are appropriate. Let me close. We're executing against the plan we laid out for 2026. The first quarter demonstrated the strength and breadth of the business. The growth drivers are performing, the pipeline is advancing. We're maintaining financial discipline while investing for the long term. We believe there are a lot of ways to win for patients at Amgen and for shareholders and staff. Over to you, Tazeen, for Q&A. Okay, perfect, Peter. I think you just discussed everything that I wanted to talk about. I knew you were going to say that. We're so glad about that. No, there's plenty to talk about. You're a big company with many exciting things going on. One of the things that I wanted to spend a couple of minutes on was Repatha, which has been outperforming now, and it looks like the pace of outperformance is increasing. Wanted to get your thoughts about where the demand is coming from and why do you think it, like, the interest in this particular asset at this time has increased with physicians and patients? Well, I think first of all, and I'll invite Casey and Jay to jump in, Repatha is, first of all, such an important medicine and what we hope is a developing cardiometabolic armamentarium for patients that Amgen's working on when we look at the rest of the pipeline. Repatha itself increased 34% year-over-year tonight, over $900 million in the first quarter, about $900 million. Strong volume growth, increasing urgency to treat patients across both secondary prevention and high-risk primary prevention. Strong prescribing momentum, new brand, new-to-brand prescriptions, this is the one that I wanted to make sure I shared with you, Tazeen, increasing roughly 45% year-over-year in the first quarter, supported by both cardiology and the primary care setting. VESALIUS-CV, the recent guideline updates, they're simply reinforcing earlier identification and treatment of high-risk patients, particularly in primary prevention, where the majority of patients are treated. Access and affordability, they're no longer gating factors. Repatha is on virtually every major U.S. formulary. Most patients are paying less than $50 a month. AmgenNow provides another avenue for patients to access Repatha. The under-penetrated thesis is so important. Approximately 100 million patients globally still not at an LDL-C goal, and PCSK9 inhibitors are still way under-penetrated. We see a long runway for growth. We expect Repatha to continue to grow through the end of the decade, as I mentioned, and we put it as our number one growth driver for the company. Where do you think peak sales could be, just based on the pace that it's at? We don't give peak sales, I would just refer you to that under-penetrated population. When we think about 100 million patients out there, and they'll be heterogeneous treatments. I know there's potential oral treatments and so forth, but we're so confident in Repatha. We're confident in the data. The data is so strong for Repatha and so compelling. You know, we're gonna continue to work as hard as we possibly can to help all those patients in those under-penetrated areas get their LDL-C down to the recommended levels. Is your sales force right-sized for the expectations that you have for growth over the next several years, or do you think that you could make tweaks to that? Our commercial group, they, as my colleague who plays hockey says, our commercial group skates to where the puck's gonna be because the head of commercial, Murdo, he's also a massive hockey fan too. We love that saying from Wayne Gretzky, they're skating to where the puck is. They're always dynamically reallocating resources to make sure they meet the needs of the prescribers and the patients to make sure we deliver that medicine around the world at the right time to the right patients. Okay. This group has overcome so many barriers, and I think that it's a incredible and special group of people that care a lot about market access, which is so vital to a medicine in secondary, now primary prevention, to really reach patients around the world. There are very few barriers now to receiving Repatha. I still sit with cardiologists that don't understand that. It had been eight years since we had guidelines. Now we have solid guidelines. They may not go far enough, but they're solid and improving and call out PCSK9 monoclonal antibodies by name. There's a radical decrease in the number of step-through requirements, virtually no prior authorizations to reach the majority of patients, and now with AmgenNow, patients can access Repatha quite independently and with a very favorable access price. This group has done a incredible amount of work in the journey of Repatha to be prepared for this moment, where with primary prevention data and the string of manuscripts that will come from that VESALIUS-CV study, awareness and the demand for Repatha is rising. Okay. Maybe one more question on commercial, then we'll go to pipeline. You guys have had a good early launch to UPLIZNA and GMG. You entered the crowded space when it was expected to become more crowded. Maybe for Jay, as you think about FcRNs, as you think about the potential of Regeneron to launch its C5 into this space late this year into early next, and other mechanisms that are earlier stage, what's giving you the confidence that the UPLIZNA approach is the right one for GMG? You've talked now many times on calls about how you expect this could become the first-line drug of choice among patients over time. Yes. I would say that, the short answer is efficacy, which is very, very strong. Though it's hard to do cross trial comparisons, the efficacy is better. Second is durability that we observed in gendered response rates only improving through the course of the first calendar year of therapy. I'd say third is convenience. Patients don't wanna experience their disease. They also don't wanna be reminded of their disease treating themselves. This medicine's given every six months after the loading dose, which is quite remarkable. Fourth is it targets the actual causal biology. Myasthenia gravis is fundamentally driven by autoreactive antibodies produced by a group of cells, B cells and pre-B cells, and UPLIZNA targeting CD19 works to deplete exactly those cells. A broader group of cells than, say, a CD20 monoclonal antibody that has that limited utility here. I think that these four really important features, I mean, any one of them could be strong enough to compel a physician to prescribe. All four of these, including the fact that to date, the medicine's been rather well-tolerated, that's big for these patients. I think that we're not surprised, but we're delighted to see the increased uptake and interest and utility of UPLIZNA. After neuromyelitis optica spectrum disorder, after IgG4-related disease, you know, after generalized myasthenia gravis, the pattern that we're observing is that diseases driven by autoreactive antibodies should respond to UPLIZNA. If you look at that list in ChatGPT or your favorite medical textbook like Harrison's, that's a long list of diseases that we're prioritizing and sequentially just line 'em up and knock 'em down. The next two for UPLIZNA will be autoimmune hepatitis and CIDP. Okay. Let's stick to GMG for one more minute. Where are you seeing the early patient pickups coming from? Are they switch patients? What are they switching from? What percent of the usage right now is in treatment naive? Thanks. I'll leave it to Casey to discuss the specifics, but we're seeing uptake in both biologically experienced and biologically naive patients. It's roughly a 50/50 split between those two groups at this point. Tazeen, it's a little bit early to be characterizing exactly what therapies individuals are switching to, but as you can imagine, with other therapies that are treated on a more frequent basis, every time they're in their physician's office is an opportunity to switch to UPLIZNA as well. Patients are looking for exactly the attributes that Jay described. Okay. On the one that you're pursuing, one of the two that you're pursuing next, CIDP, also one that's been dominated by FcRNs, you also have IVIG as a indicated usage drug. How are you thinking about the dynamics of that market versus what you're seeing so far with GMG? I'd say more similar than different. I mean, the medicine has to work there, but it targets, again, the underlying biology. It meets the patient where they're at with a convenient dosing schema. I should hope that if active, the durability would be another strong feature, given the pharmacodynamic suppression of CD19 positive B cells is so durable with this afucosylated monoclonal antibody. I would say, you know, provided strong efficacy, which is really the anchor of why this medicine is so desirable in myasthenia gravis, generalized myasthenia gravis, you know, I think in CIDP it stands to be very much the same story. When should we expect to see data on that? We haven't as yet indicated when that study will read out. Yeah, we'll be starting those two phase III studies later this year. Okay. Are those the extent of indications that you'd wanna pursue for UPLIZNA, or are there others behind it? No, there are additional indications for UPLIZNA, and I would also share that because we've been in CD19 for so long, and you must know we have an FDA-approved and broadly utilized standard of care frontline acute lymphoblastic leukemia CD19 called blinatumomab, BLINCYTO for its leukemia use case and intravenous continuous infusion, that in our fridges and in our labs, we have a number of molecules targeting this target and this pathway, and have built a whole program around B-cell depletion leveraging CD19. Some of those diseases will track very nicely to an UPLIZNA use case, and others will use a pipeline agent. I would expect to see, you know, proof of concept, if not additional data, in lupus with and without nephritis and other disease states. Okay. Yeah. All right. Now let's move on to some of your pipeline assets. Let's start with MariTide. There seems to be a bifurcated reaction to this drug. It's either this is great, it's going to be a market share leader in the obesity space, or, well, there's not enough data right now for us to kind of know where it's going to land. What is the real differentiation? You've got a mechanism, GLP, but it's going to be dosed less frequently. How is that going to compare to a multitude of other companies that might hope to launch around the same time as you guys would? Maybe help the market better understand this drug. Mechanistically, why do you think it could have some advantages over just being another GLP on the market? Thank you. Well, I would start by saying that MariTide is a very special molecule, and it's not that complicated. It's a GIP antagonist antibody with GLP-1 agonist peptides that has dramatic efficacy on weight loss, is extremely well tolerated at target doses, that benefits from dose escalation just like all the other ones, and it's given less frequently. I don't think we should overcomplicate it. It's very simple. If GLP-1 peptides were twice a day, they'd be less exciting than every week. If a medicine that exploits this mechanism can be given monthly or as Peter shared, maybe every eight weeks, where we've already shown and presented data demonstrating real efficacy, maybe every 12 weeks, as we've indicated, we've some maintenance data that gives us some conviction there, and we continue to study every eight and every 12 weeks in prospective and now phase III trials. I wouldn't overcomplicate it. It's a very active incretin-based weight loss medicine that is just given less frequently. That's very special. The antibody core affords an opportunity for patients not to inject themselves every single week. As we continue to see in real-world evidence, weekly injectables are challenging for patients to stay on. If half of patients are stopping the use of these medicines at six months or 12 months, are the patients getting what they need, the protection for these serious diseases? Are the payers getting what they deserve for providing access to these medicines? You know, the features of MariTide could improve patient persistence, and for chronic diseases, that really matters. I wouldn't overcomplicate it, an incretin-based medicine that is given less frequently. Okay. As said by a CFO. As simple as it gets. Tazeen Ahmad, think 52, 12, 6, 4. Which one of those do you want if you're getting poked? Yeah, it's a fair point. When I got my flu shot, I didn't ask if it could be weekly, you know? Let's see how the data appears when we read out these phase III studies, but we are very confident in the profile of this medicine, the design of these trials. Their execution has gone very well, I wouldn't overcomplicate it. Okay. Yeah. What about the tolerability profile? I think there's been some questions about it. You're looking at various titrations, Govada. Anything you could share on that front? Yeah. I'd break tolerability into two conversations. One is tolerability at target dose. It's extremely well tolerated at target dose. You could be on 350 mg of this. You could get it every single month. As we've shown with the Manhattan plots from phase II, the drug is just innocuous, just very well tolerated by patients. The reason for this is it's an antibody core, so you're just kind of marinating in it. It's just smooth exposure. When you do a pill or a weekly injectable, there's a spike. A medicine is absorbed, and then it's metabolized. Absorbed, and then it's metabolized. The part of the brain that experiences nausea and vomiting is called the area postrema in the hypothalamus, and it responds to these jolts. If we see, let's say, the data from oral GLP-1s as presented to date, and you look at their Manhattan plots, which is how symptoms are tracked over time, there's just a scattering persistence of nausea and vomiting. I think some data was even disclosed today about switching from injectables to orals, and there was real associated, almost 19% nausea and significant vomiting moving to more frequent dosing. MariTide at target dose is just smooth exposure and a smooth experience. Upfront treatment. Here, MariTide is more similar than different to other injectables, that to get a GLP-1 medicine on board, you need to start low and go slow with dose titration. We've learned, as every other company has, prosecuting this mechanism, that no dose escalation is worse than 1-step, that 2-step is better than 1-step, and as we shared on our earnings call, that 3-step is unsurprisingly better than 2-step. We employ 3-step dose escalation in our phase III studies, and have real confidence that the upfront experience with MariTide will be competitive and the on-treatment experience will be extraordinary. Okay. Let's talk about the opportunity for it to be used in a maintenance setting. Yeah. You know, none of these diseases go away after 52 or 72 weeks, which is how we're studying these medicines in clinical investigation. In this room and rooms like it, those numbers matter, and we're gonna deliver great numbers. In clinical practice, these physicians are seeing patients, and these patients are experiencing these diseases for a whole lifetime. How patients can remain on therapy and derive durable benefit for their whole lifetime, because we're not curing obesity with these medicines, but we are effectively treating it. We are effectively treating associated diabetes and many other related conditions. We and others have become very interested for what happens after the primary endpoint. Through long-term extensions and now dedicated phase III clinical investigation, we intend to characterize the benefits of MariTide when used for an additional year after a year of treatment or beyond. There, we believe that one might even require less MariTide than the acute and treatment phase because the long-lasting antibody has long-lasting effects. We've seen data in phase II clinical investigation in our part II extension, that every eight-week and even every 12-week dosing can maintain lost weight. The field of obesity is not surprised by this because they've talked about this metabolic set point for a long, long time, and these medicines are reducing that set point and then keeping the weight off. We now want to follow up on this strong signal in two ways. One is could maintenance MariTide be less frequent than treatment MariTide? Second, if we can switch from MariTide to a less frequent MariTide, could we get people off weekly injectables to a much more convenient maintenance MariTide? We announced at our earnings call that we're initiating clinical investigation on a maintenance as well as on a switching to MariTide experience that will feature less frequent dosing. This is very important to translate efficacy, which is what you see on a clinical trial, to effectiveness, how well medicines can work in the real world. Okay. Thanks for all that color. How long do you expect this maintenance study that you announced to last? Well, we have I think reported on clinicaltrials.gov the length of the maintenance studies, and they'll be about a calendar year. Okay. In terms of pace of enrollment, do you think that this is gonna be quickly enrolled? You know, the long-term extensions are invitations to patients who've been on the phase III clinical trial to continue. There we expect real followership, really strong participation. When we did our phase II clinical study and we offered patients to complete onto a maintenance, I think we had more than 90% conversion. Is that right, Casey? That's correct. Yeah, more than 90% participation. You get an email or your doctor or clinician asks you, "Could you be interested to keep taking this medicine for a year?" More than 90% signed up for that, which is people voting with their feet and their thumbs. We're expecting very strong participation. In fact, all of our clinical studies of MariTide have enrolled ahead of expectations. These are a strong set of clinical trials. We'll stay tuned on updates from these studies as we go forward. Let's maybe take a minute to talk about a couple of other pipeline assets and indications. I wanted to maybe spend a little bit of time on Lp(a) because. Yeah. You've got a competitor that's gonna have data coming, I think, later this year, for which nearly everyone expects there to be a read-through for Amgen. Rather than me talking to investors about what the right read-through should be, I thought I would ask you, Jay. What is the right read-through to be thinking about when we see the Novartis data released? Yes. For Lp(a) later this year? No, know that medicine well, and I'm following that research very closely as are, as is this community. I would say that the read-through from the Novartis readout midyear will be sort of directional, but not absolute as to what to expect from our OCEAN(a) study. That is forecast to read out later. It's event-driven study. The reason for that is that, number one, we're both testing a really strong hypothesis with very effective medicines. Lp(a), a genetically defined risk factor for atherosclerotic cardiovascular disease, each Lp(a) particle is 6x more atherogenic pound for pound than an LDL-C particle. Look at all that we know about LDL-C and its reduction and its management. Experiments of nature have shown that a gradient, that as Lp(a) ramps up in our bloodstreams, our risk for heart disease ramps up in parallel. Both of these companies are testing the same hypothesis. I like our chances. Our medicine is quite a bit more potent than the Novartis medicine. If that medicine, pelacarsen, reduces Lp(a) 70%-75%, our medicine, olpasiran, flatlines Lp(a) more than 95%. Could matter. Second is, our study has a slightly different endpoint. Novartis uses a 4-point MACE endpoint, major adverse cardiovascular events. We're using a 3-point endpoint. We didn't see, from an epidemiologic standpoint, quite as much weight around stroke, and so we've thought to consolidate all of our alpha around the endpoints that we think will really move the needle for patients. In that regard, it Novartis is a good company with a good molecule, asking a good question, and so we're very interested to see the outcome. The guidance we think would be for us, would be directional. Okay. Yeah. When the data does come out, you know, does that allow you to make any changes if you need to? Would you think you would want to? You know, I think a late-stage protocol amendment would not be our preferred path forward. We are very confident in the design of this trial. It's an event-driven study. Yeah. I think some folks had expected maybe it could come out later this year, but now I think expectations are some time into next year. When would you have a better sense of guiding towards a data readout? You know, we, there's a monitoring committee that's tracking these events. We're performing this study in collaboration with the leading global cardiovascular group. We and they have executed through the development of Repatha cardiovascular outcome trials in a very expert way. We are forecasting it's, the event rate is not gonna read out this year, and we'll have more to say about the readout as the aperture narrows on the target date that, which is a certain number of events. Okay. Maybe last question really quickly, how big do you think this opportunity is? You know, one in five humans is born with an elevated Lp(a), and we are studying secondary prevention first. Should that be positive, as for LDL-C, I would have a hard time explaining scientifically why that mechanism wouldn't work in primary prevention, which is a much bigger number of people. It's a big opportunity. Would you put it on the same level as, you know, LDL, like statins and those types of drugs, or bigger? It feels like that. you know, it feels like that, but, Casey, what would you say? I'd say it would be dependent upon the phase III data. Of course. Well said. I guess if you needed to build a sales force for that, what kind of investment would you need? I would say, and it's a good point, if you think about Repatha and what Peter described in terms of our cardiometabolic foundation that we built, very strong cardiology presence, very strong primary care presence. You can layer in olpasiran on top of that, and then also think about MariTide and the various metabolic diseases that we're studying with MariTide, would also fit right in. We feel like we have the potential to have a very strong cardiometabolic presence in general, especially if we're successful with MariTide and with olpasiran on top of what we built with Repatha. Yeah, actually you bring up a good point. What type of overlap would there be in physicians prescribing Repatha and who might prescribe it for Lp(a)? It would be a high degree of overlap. Lipid management clinics are now measuring Lp(a), and the current guidelines from the AHA, one thing they got just absolutely right was recommending that patients know their Lp(a) number, as all of us in this room should. Because even without effective medicines that we hope to have in the near term, knowing you have an elevated genetically defined risk that you can't eat better and it goes away, stop smoking, it goes away, even Repatha doesn't make it go away, you approach your life a little bit differently perhaps. Maybe you do an extra 15 minutes on the treadmill every morning. I think knowing about Lp(a) is very important, and in that way, the community's activated. Lp(a) measurement is in the guidelines, and that leads to the question, okay, so what can we do about it? Okay. With that, we're out of time. Thanks, gentlemen, for joining me today. Thank- Thanks, everyone, for listening. Thank you, Tazeen, and thank you, Bo.

Speaker 4: Care Conference. I'm Tazeen Ahmad. I'm one of the senior biotech analysts here at the bank. It's my pleasure to have our next presenting company, Amgen. Sitting up on stage are several members from the Amgen team. Thanks in advance for making the trip over from California. We really appreciate it. We have Peter Griffith, who is Executive Vice President and CFO. We have Jay Bradner, who's Executive President of Research and Development. We of course have Casey Capparelli, who is Vice President, Investor Relations. Gentlemen, thank you for making the trip again. Care Conference. care conference I'm Tazeen Ahmad. i'm tazeen ahmad I'm one of the senior biotech analysts here at the bank. i'm one of the senior biotech analysts here at the bank It's my pleasure to have our next presenting company, Amgen. it's my pleasure to have our next presenting company amgen Sitting up on stage are several members from the Amgen team. sitting up on stage are several members from the amgen team Thanks in advance for making the trip over from California. thanks in advance for making the trip over from california We really appreciate it. we really appreciate it We have Peter Griffith, who is Executive Vice President and CFO. we have peter griffith who is executive vice president and cfo We have Jay Bradner, who's Executive President of Research and Development. we have jay bradner who's executive president of research and development We of course have Casey Capparelli , who is Vice President, Investor Relations. we of course have casey capparelli who is vice president investor relations Gentlemen, thank you for making the trip again. gentlemen thank you for making the trip again

Speaker 3: Thank you for having us. Thank you for having us. thank you for having us

Speaker 4: Okay. Maybe we could do a quick overview of the company and, some important, comments that you or statements that you need to make before we go into more detail. I'll turn it over to Peter for that. Okay. okay Maybe we could do a quick overview of the company and, some important, comments that you or statements that you need to make before we go into more detail. maybe we could do a quick overview of the company and some important comments that you or statements that you need to make before we go into more detail I'll turn it over to Peter for that. i'll turn it over to peter for that

Speaker 3: Great, Tazeen. Thank you. Good morning, everyone. I would just add, coming over to Las Vegas, there's traffic coming over, but in today's world, there's a lot less going back. Great, Tazeen. great tazeen Thank you. thank you Good morning, everyone. good morning everyone I would just add, coming over to Las Vegas, there's traffic coming over, but in today's world, there's a lot less going back. i would just add coming over to las vegas there's traffic coming over but in today's world there's a lot less going back

Speaker 4: Okay. Okay. okay

Speaker 3: So, uh, we'll take- So, uh, we'll take- so uh we'll take-

Speaker 4: It'll be a quick trip home. It'll be a quick trip home. it'll be a quick trip home

Speaker 3: We'll take advantage of that. Thank you for having us. We are glad to be here. I've got a few prepared remarks I just want to run through and cover before we go to Q&A. We believe, first of all, there are a lot of ways for us to win, and look forward to the discussion around that, and especially winning for patients. We're pleased with the strong first quarter performance, which reinforces 2026 as a springboard year for Amgen. This is a year in which we expect the rapidly growing products we have to offset the impact of the patent expirations and increase competition. In the first quarter, we did exactly that. Revenue was up 6% year-over-year. Product sales were up 4% year-over-year. Non-GAAP earnings per share was up 5% year-over-year. Strong financial discipline exercise by the company. We'll take advantage of that. we'll take advantage of that Thank you for having us. thank you for having us We are glad to be here. we are glad to be here I've got a few prepared remarks I just want to run through and cover before we go to Q&A. i've got a few prepared remarks i just want to run through and cover before we go to q&a We believe, first of all, there are a lot of ways for us to win, and look forward to the discussion around that, and especially winning for patients. we believe first of all there are a lot of ways for us to win and look forward to the discussion around that and especially winning for patients We're pleased with the strong first quarter performance, which reinforces 2026 as a springboard year for Amgen. we're pleased with the strong first quarter performance which reinforces 2026 as a springboard year for amgen This is a year in which we expect the rapidly growing products we have to offset the impact of the patent expirations and increase competition. this is a year in which we expect the rapidly growing products we have to offset the impact of the patent expirations and increase competition In the first quarter, we did exactly that. in the first quarter we did exactly that Revenue was up 6% year-over-year. revenue was up 6% year-over-year Product sales were up 4% year-over-year. product sales were up 4% year-over-year Non-GAAP earnings per share was up 5% year-over-year. non-gaap earnings per share was up 5% year-over-year Strong financial discipline exercise by the company. strong financial discipline exercise by the company We've got significant breadth and depth across the portfolio. 16 products delivered double-digit or better sales growth in the first quarter year-over-year. 17 products annualizing at $1 billion or more in the first quarter based on first quarter sales. Importantly, our six key growth drivers, Repatha, Evenity, Tezspire, and then our innovative oncology, rare disease, and biosimilars portfolios accounted for nearly 70% of our product sales in the first quarter, and they grew at 24%, an aggregate rate of 24% growth on those six growth driver categories in the first quarter. Repatha, Evenity, and Tezspire each hold leadership positions in under-penetrated disease areas where there are millions of patients yet to be treated. These medicines all grew at 20% or more in the quarter and are well-positioned for continued growth this year and through the decade. We've got significant breadth and depth across the portfolio. 16 products delivered double-digit or better sales growth in the first quarter year-over-year. 17 products annualizing at $1 billion or more in the first quarter based on first quarter sales. we've got significant breadth and depth across the portfolio 16 products delivered double-digit or better sales growth in the first quarter year-over-year 17 products annualizing at $1 billion or more in the first quarter based on first quarter sales Importantly, our six key growth drivers, Repatha, Evenity, Tezspire, and then our innovative oncology, rare disease, and biosimilars portfolios accounted for nearly 70% of our product sales in the first quarter, and they grew at 24%, an aggregate rate of 24% growth on those six growth driver categories in the first quarter. importantly our six key growth drivers repatha evenity tezspire and then our innovative oncology rare disease and biosimilars portfolios accounted for nearly 70% of our product sales in the first quarter and they grew at 24% an aggregate rate of 24% growth on those six growth driver categories in the first quarter Repatha, Evenity, and Tezspire each hold leadership positions in under-penetrated disease areas where there are millions of patients yet to be treated. repatha evenity and tezspire each hold leadership positions in under-penetrated disease areas where there are millions of patients yet to be treated These medicines all grew at 20% or more in the quarter and are well-positioned for continued growth this year and through the decade. these medicines all grew at 20% or more in the quarter and are well-positioned for continued growth this year and through the decade Our rare disease portfolio grew 25% year-over-year. We see significant opportunities ahead as we scale those therapies and this category by reaching additional patients, expanding into new indications, and launching into new geographies. UPLIZNA exemplifies this opportunity. It's experiencing continued growth across multiple B-cell-mediated autoimmune diseases. Pretty good for CFO Jay. Our rare disease portfolio grew 25% year-over-year. our rare disease portfolio grew 25% year-over-year We see significant opportunities ahead as we scale those therapies and this category by reaching additional patients, expanding into new indications, and launching into new geographies. we see significant opportunities ahead as we scale those therapies and this category by reaching additional patients expanding into new indications and launching into new geographies UPLIZNA exemplifies this opportunity. uplizna exemplifies this opportunity It's experiencing continued growth across multiple B-cell-mediated autoimmune diseases. it's experiencing continued growth across multiple b-cell-mediated autoimmune diseases Pretty good for CFO Jay. pretty good for cfo jay

Speaker 2: Pretty good. Pretty good. Pretty good. pretty good Pretty good. pretty good

Speaker 3: In Innovative oncology, our portfolio grew 25% year-over-year, driven by our bispecific T-cell engager portfolio or BiTE medicines, which are expanding what is possible for patients across multiple cancers. We remain particularly encouraged by IMDELLTRA, which is rapidly becoming a standard of care in late-line small cell lung cancer. Our biosimilars portfolio remains strong, driven by sales of PAVBLU this year. It's generated sales in excess of $14 billion cumulatively since we launched them in 2018. In Innovative oncology, our portfolio grew 25% year-over-year, driven by our bispecific T-cell engager portfolio or BiTE medicines, which are expanding what is possible for patients across multiple cancers. in innovative oncology our portfolio grew 25% year-over-year driven by our bispecific t-cell engager portfolio or bite medicines which are expanding what is possible for patients across multiple cancers We remain particularly encouraged by IMDELLTRA, which is rapidly becoming a standard of care in late-line small cell lung cancer. we remain particularly encouraged by imdelltra which is rapidly becoming a standard of care in late-line small cell lung cancer Our biosimilars portfolio remains strong, driven by sales of PAVBLU this year. our biosimilars portfolio remains strong driven by sales of pavblu this year It's generated sales in excess of $14 billion cumulatively since we launched them in 2018. it's generated sales in excess of $14 billion cumulatively since we launched them in 2018 The portfolio is an important contributor to our growth, as well-positioned as the next wave of biosimilar candidates advances through phase III development. Let's turn to the pipeline. Our confidence continues to build in MariTide as a differentiated treatment for obesity, type 2 diabetes, and obesity-related conditions. We're executing effectively across the enterprise from clinical development to manufacturing as we advance MariTide's broad phase III program and build and optimize our manufacturing capacity ahead of launch. We expect MariTide to be important for weight loss induction, long-term weight maintenance, and for patients switching from weekly GLP-1 therapies to MariTide. With the potential for as few as four or six injections per year, our approach reflects how obesity care may evolve. Patients need effective initial weight loss and practical, durable maintenance options. The portfolio is an important contributor to our growth, as well-positioned as the next wave of biosimilar candidates advances through phase III development. the portfolio is an important contributor to our growth as well-positioned as the next wave of biosimilar candidates advances through phase iii development Let's turn to the pipeline. let's turn to the pipeline Our confidence continues to build in MariTide as a differentiated treatment for obesity, type 2 diabetes, and obesity-related conditions. our confidence continues to build in maritide as a differentiated treatment for obesity type 2 diabetes and obesity-related conditions We're executing effectively across the enterprise from clinical development to manufacturing as we advance MariTide's broad phase III program and build and optimize our manufacturing capacity ahead of launch. we're executing effectively across the enterprise from clinical development to manufacturing as we advance maritide's broad phase iii program and build and optimize our manufacturing capacity ahead of launch We expect MariTide to be important for weight loss induction, long-term weight maintenance, and for patients switching from weekly GLP-1 therapies to MariTide. we expect maritide to be important for weight loss induction long-term weight maintenance and for patients switching from weekly glp-1 therapies to maritide With the potential for as few as four or six injections per year, our approach reflects how obesity care may evolve. with the potential for as few as four or six injections per year our approach reflects how obesity care may evolve Patients need effective initial weight loss and practical, durable maintenance options. patients need effective initial weight loss and practical durable maintenance options Beyond MariTide, we see strong potential across a number of other programs in late-stage development, including olpasiran, our Lp-lowering medicine in phase III development, dazodalibep in phase III for Sjögren's disease, and xaluritamig, which is in phase III for late-stage prostate cancer. On the tax front, there are two related matters with the same core issue, value attribution. The IRS is arguing that our Puerto Rico operations should be treated as if they were essentially a limited value contract manufacturer. We strongly disagree with that position. We've got 2,500 plus colleagues who are United States citizens there, the majority with technical degrees. It's a very complex operation. There are two tax periods in question, 2010-2015 and 2016-2018. Beyond MariTide, we see strong potential across a number of other programs in late-stage development, including olpasiran, our Lp-lowering medicine in phase III development, dazodalibep in phase III for Sjögren's disease, and xaluritamig, which is in phase III for late-stage prostate cancer. beyond maritide we see strong potential across a number of other programs in late-stage development including olpasiran our lp-lowering medicine in phase iii development dazodalibep in phase iii for sjögren's disease and xaluritamig which is in phase iii for late-stage prostate cancer On the tax front, there are two related matters with the same core issue, value attribution. on the tax front there are two related matters with the same core issue value attribution The IRS is arguing that our Puerto Rico operations should be treated as if they were essentially a limited value contract manufacturer. the irs is arguing that our puerto rico operations should be treated as if they were essentially a limited value contract manufacturer We strongly disagree with that position. we strongly disagree with that position We've got 2,500 plus colleagues who are United States citizens there, the majority with technical degrees. we've got 2,500 plus colleagues who are united states citizens there the majority with technical degrees It's a very complex operation. it's a very complex operation There are two tax periods in question, 2010-2015 and 2016-2018. there are two tax periods in question 2010-2015 and 2016-2018 The 2010 through 2015 tax court matter is not new. There have been no changes in our position on the status of that case. It's been fully tried and litigated. We remain highly confident in the case we presented at trial, and we continue to expect a decision no earlier than the second half of 2026. As expected in the ordinary course of the IRS audit process, we received a draft notice of proposed adjustment, what I call a NOPA, in April, for similar transfer pricing issues for the 2016-2018 period. It's just an early step in what we would expect to be a multi-year process. It's not a final determination. Importantly, our commitment to Puerto Rico continues to grow. The 2010 through 2015 tax court matter is not new. the 2010 through 2015 tax court matter is not new There have been no changes in our position on the status of that case. there have been no changes in our position on the status of that case It's been fully tried and litigated. it's been fully tried and litigated We remain highly confident in the case we presented at trial, and we continue to expect a decision no earlier than the second half of 2026. As expected in the ordinary course of the IRS audit process, we received a draft notice of proposed adjustment, what I call a NOPA, in April, for similar transfer pricing issues for the 2016- 2018 period. we remain highly confident in the case we presented at trial and we continue to expect a decision no earlier than the second half of 2026. as expected in the ordinary course of the irs audit process we received a draft notice of proposed adjustment what i call a nopa in april for similar transfer pricing issues for the 2016- 2018 period It's just an early step in what we would expect to be a multi-year process. it's just an early step in what we would expect to be a multi-year process It's not a final determination. it's not a final determination Importantly, our commitment to Puerto Rico continues to grow. importantly our commitment to puerto rico continues to grow Since our first quarter call, we announced an additional $300 million in investment, building on the previously announced $650 million in our Puerto Rico facility. Puerto Rico is a core part of Amgen's U.S. manufacturing network, with advanced manufacturing capabilities for biologics, deep expertise all the way around. We strongly disagree with any characterization of these operations as limited value contract manufacturing. We continue to believe the IRS claims are without merit and our reserves are appropriate. Let me close. We're executing against the plan we laid out for 2026. The first quarter demonstrated the strength and breadth of the business. The growth drivers are performing, the pipeline is advancing. We're maintaining financial discipline while investing for the long term. Since our first quarter call, we announced an additional $300 million in investment, building on the previously announced $650 million in our Puerto Rico facility. since our first quarter call we announced an additional $300 million in investment building on the previously announced $650 million in our puerto rico facility Puerto Rico is a core part of Amgen's U.S. manufacturing network, with advanced manufacturing capabilities for biologics, deep expertise all the way around. puerto rico is a core part of amgen's u.s manufacturing network with advanced manufacturing capabilities for biologics deep expertise all the way around We strongly disagree with any characterization of these operations as limited value contract manufacturing. we strongly disagree with any characterization of these operations as limited value contract manufacturing We continue to believe the IRS claims are without merit and our reserves are appropriate. we continue to believe the irs claims are without merit and our reserves are appropriate Let me close. let me close We're executing against the plan we laid out for 2026. we're executing against the plan we laid out for 2026 The first quarter demonstrated the strength and breadth of the business. the first quarter demonstrated the strength and breadth of the business The growth drivers are performing, the pipeline is advancing. the growth drivers are performing the pipeline is advancing We're maintaining financial discipline while investing for the long term. we're maintaining financial discipline while investing for the long term We believe there are a lot of ways to win for patients at Amgen and for shareholders and staff. Over to you, Tazeen, for Q&A. We believe there are a lot of ways to win for patients at Amgen and for shareholders and staff. we believe there are a lot of ways to win for patients at amgen and for shareholders and staff Over to you, Tazeen, for Q&A. over to you tazeen for q&a

Speaker 4: Okay, perfect, Peter. I think you just discussed everything that I wanted to talk about. Okay, perfect, Peter. okay perfect peter I think you just discussed everything that I wanted to talk about. i think you just discussed everything that i wanted to talk about

Speaker 3: I knew you were going to say that. We're so glad about that. I knew you were going to say that. i knew you were going to say that We're so glad about that. we're so glad about that

Speaker 4: No, there's plenty to talk about. You're a big company with many exciting things going on. One of the things that I wanted to spend a couple of minutes on was Repatha, which has been outperforming now, and it looks like the pace of outperformance is increasing. Wanted to get your thoughts about where the demand is coming from and why do you think it, like, the interest in this particular asset at this time has increased with physicians and patients? No, there's plenty to talk about. no there's plenty to talk about You're a big company with many exciting things going on. you're a big company with many exciting things going on One of the things that I wanted to spend a couple of minutes on was Repatha, which has been outperforming now, and it looks like the pace of outperformance is increasing. one of the things that i wanted to spend a couple of minutes on was repatha which has been outperforming now and it looks like the pace of outperformance is increasing Wanted to get your thoughts about where the demand is coming from and why do you think it, like, the interest in this particular asset at this time has increased with physicians and patients? wanted to get your thoughts about where the demand is coming from and why do you think it like the interest in this particular asset at this time has increased with physicians and patients

Speaker 3: Well, I think first of all, and I'll invite Casey and Jay to jump in, Repatha is, first of all, such an important medicine and what we hope is a developing cardiometabolic armamentarium for patients that Amgen's working on when we look at the rest of the pipeline. Repatha itself increased 34% year-over-year tonight, over $900 million in the first quarter, about $900 million. Strong volume growth, increasing urgency to treat patients across both secondary prevention and high-risk primary prevention. Strong prescribing momentum, new brand, new-to-brand prescriptions, this is the one that I wanted to make sure I shared with you, Tazeen, increasing roughly 45% year-over-year in the first quarter, supported by both cardiology and the primary care setting. Well, I think first of all, and I'll invite Casey and Jay to jump in, Repatha is, first of all, such an important medicine and what we hope is a developing cardiometabolic armamentarium for patients that Amgen's working on when we look at the rest of the pipeline. well i think first of all and i'll invite casey and jay to jump in repatha is first of all such an important medicine and what we hope is a developing cardiometabolic armamentarium for patients that amgen's working on when we look at the rest of the pipeline Repatha itself increased 34% year-over-year tonight, over $900 million in the first quarter, about $900 million. repatha itself increased 34% year-over-year tonight over $900 million in the first quarter about $900 million Strong volume growth, increasing urgency to treat patients across both secondary prevention and high-risk primary prevention. strong volume growth increasing urgency to treat patients across both secondary prevention and high-risk primary prevention Strong prescribing momentum, new brand, new-to-brand prescriptions, this is the one that I wanted to make sure I shared with you, Tazeen, increasing roughly 45% year-over-year in the first quarter, supported by both cardiology and the primary care setting. strong prescribing momentum new brand new-to-brand prescriptions this is the one that i wanted to make sure i shared with you tazeen increasing roughly 45% year-over-year in the first quarter supported by both cardiology and the primary care setting VESALIUS-CV, the recent guideline updates, they're simply reinforcing earlier identification and treatment of high-risk patients, particularly in primary prevention, where the majority of patients are treated. Access and affordability, they're no longer gating factors. Repatha is on virtually every major U.S. formulary. Most patients are paying less than $50 a month. AmgenNow provides another avenue for patients to access Repatha. The under-penetrated thesis is so important. Approximately 100 million patients globally still not at an LDL-C goal, and PCSK9 inhibitors are still way under-penetrated. We see a long runway for growth. We expect Repatha to continue to grow through the end of the decade, as I mentioned, and we put it as our number one growth driver for the company. VESALIUS-CV, the recent guideline updates, they're simply reinforcing earlier identification and treatment of high-risk patients, particularly in primary prevention, where the majority of patients are treated. vesalius-cv the recent guideline updates they're simply reinforcing earlier identification and treatment of high-risk patients particularly in primary prevention where the majority of patients are treated Access and affordability, they're no longer gating factors. access and affordability they're no longer gating factors Repatha is on virtually every major U.S. formulary. repatha is on virtually every major u.s formulary Most patients are paying less than $50 a month. most patients are paying less than $50 a month AmgenNow provides another avenue for patients to access Repatha. amgennow provides another avenue for patients to access repatha The under-penetrated thesis is so important. the under-penetrated thesis is so important Approximately 100 million patients globally still not at an LDL-C goal, and PCSK9 inhibitors are still way under-penetrated. approximately 100 million patients globally still not at an ldl-c goal and pcsk9 inhibitors are still way under-penetrated We see a long runway for growth. we see a long runway for growth We expect Repatha to continue to grow through the end of the decade, as I mentioned, and we put it as our number one growth driver for the company. we expect repatha to continue to grow through the end of the decade as i mentioned and we put it as our number one growth driver for the company

Speaker 4: Where do you think peak sales could be, just based on the pace that it's at? Where do you think peak sales could be, just based on the pace that it's at? where do you think peak sales could be just based on the pace that it's at

Speaker 3: We don't give peak sales, I would just refer you to that under-penetrated population. When we think about 100 million patients out there, and they'll be heterogeneous treatments. I know there's potential oral treatments and so forth, but we're so confident in Repatha. We're confident in the data. The data is so strong for Repatha and so compelling. You know, we're gonna continue to work as hard as we possibly can to help all those patients in those under-penetrated areas get their LDL-C down to the recommended levels. We don't give peak sales, I would just refer you to that under-penetrated population. we don't give peak sales i would just refer you to that under-penetrated population When we think about 100 million patients out there, and they'll be heterogeneous treatments. when we think about 100 million patients out there and they'll be heterogeneous treatments I know there's potential oral treatments and so forth, but we're so confident in Repatha. i know there's potential oral treatments and so forth but we're so confident in repatha We're confident in the data. we're confident in the data The data is so strong for Repatha and so compelling. the data is so strong for repatha and so compelling You know, we're gonna continue to work as hard as we possibly can to help all those patients in those under-penetrated areas get their LDL-C down to the recommended levels. you know we're gonna continue to work as hard as we possibly can to help all those patients in those under-penetrated areas get their ldl-c down to the recommended levels

Speaker 4: Is your sales force right-sized for the expectations that you have for growth over the next several years, or do you think that you could make tweaks to that? Is your sales force right-sized for the expectations that you have for growth over the next several years, or do you think that you could make tweaks to that? is your sales force right-sized for the expectations that you have for growth over the next several years or do you think that you could make tweaks to that

Speaker 3: Our commercial group, they, as my colleague who plays hockey says, our commercial group skates to where the puck's gonna be because the head of commercial, Murdo, he's also a massive hockey fan too. We love that saying from Wayne Gretzky, they're skating to where the puck is. They're always dynamically reallocating resources to make sure they meet the needs of the prescribers and the patients to make sure we deliver that medicine around the world at the right time to the right patients. Our commercial group, they, as my colleague who plays hockey says, our commercial group skates to where the puck's gonna be because the head of commercial, Murdo, he's also a massive hockey fan too. our commercial group they as my colleague who plays hockey says our commercial group skates to where the puck's gonna be because the head of commercial murdo he's also a massive hockey fan too We love that saying from Wayne Gretzky, they're skating to where the puck is. we love that saying from wayne gretzky they're skating to where the puck is They're always dynamically reallocating resources to make sure they meet the needs of the prescribers and the patients to make sure we deliver that medicine around the world at the right time to the right patients. they're always dynamically reallocating resources to make sure they meet the needs of the prescribers and the patients to make sure we deliver that medicine around the world at the right time to the right patients

Speaker 4: Okay. Okay. okay

Speaker 2: This group has overcome so many barriers, and I think that it's a incredible and special group of people that care a lot about market access, which is so vital to a medicine in secondary, now primary prevention, to really reach patients around the world. There are very few barriers now to receiving Repatha. I still sit with cardiologists that don't understand that. It had been eight years since we had guidelines. Now we have solid guidelines. They may not go far enough, but they're solid and improving and call out PCSK9 monoclonal antibodies by name. There's a radical decrease in the number of step-through requirements, virtually no prior authorizations to reach the majority of patients, and now with AmgenNow, patients can access Repatha quite independently and with a very favorable access price. This group has overcome so many barriers, and I think that it's a incredible and special group of people that care a lot about market access, which is so vital to a medicine in secondary, now primary prevention, to really reach patients around the world. this group has overcome so many barriers and i think that it's a incredible and special group of people that care a lot about market access which is so vital to a medicine in secondary now primary prevention to really reach patients around the world There are very few barriers now to receiving Repatha. there are very few barriers now to receiving repatha I still sit with cardiologists that don't understand that. i still sit with cardiologists that don't understand that It had been eight years since we had guidelines. it had been eight years since we had guidelines Now we have solid guidelines. now we have solid guidelines They may not go far enough, but they're solid and improving and call out PCSK9 monoclonal antibodies by name. they may not go far enough but they're solid and improving and call out pcsk9 monoclonal antibodies by name There's a radical decrease in the number of step-through requirements, virtually no prior authorizations to reach the majority of patients, and now with AmgenNow, patients can access Repatha quite independently and with a very favorable access price. there's a radical decrease in the number of step-through requirements virtually no prior authorizations to reach the majority of patients and now with amgennow patients can access repatha quite independently and with a very favorable access price This group has done a incredible amount of work in the journey of Repatha to be prepared for this moment, where with primary prevention data and the string of manuscripts that will come from that VESALIUS-CV study, awareness and the demand for Repatha is rising. This group has done a incredible amount of work in the journey of Repatha to be prepared for this moment, where with primary prevention data and the string of manuscripts that will come from that VESALIUS-CV study, awareness and the demand for Repatha is rising. this group has done a incredible amount of work in the journey of repatha to be prepared for this moment where with primary prevention data and the string of manuscripts that will come from that vesalius-cv study awareness and the demand for repatha is rising

Speaker 4: Okay. Maybe one more question on commercial, then we'll go to pipeline. You guys have had a good early launch to UPLIZNA and GMG. You entered the crowded space when it was expected to become more crowded. Maybe for Jay, as you think about FcRNs, as you think about the potential of Regeneron to launch its C5 into this space late this year into early next, and other mechanisms that are earlier stage, what's giving you the confidence that the UPLIZNA approach is the right one for GMG? You've talked now many times on calls about how you expect this could become the first-line drug of choice among patients over time. Okay. okay Maybe one more question on commercial, then we'll go to pipeline. maybe one more question on commercial then we'll go to pipeline You guys have had a good early launch to UPLIZNA and GMG. You entered the crowded space when it was expected to become more crowded. you guys have had a good early launch to uplizna and gmg. you entered the crowded space when it was expected to become more crowded Maybe for Jay, as you think about FcRNs, as you think about the potential of Regeneron to launch its C5 into this space late this year into early next, and other mechanisms that are earlier stage, what's giving you the confidence that the UPLIZNA approach is the right one for GMG? maybe for jay as you think about fcrns as you think about the potential of regeneron to launch its c5 into this space late this year into early next and other mechanisms that are earlier stage what's giving you the confidence that the uplizna approach is the right one for gmg You've talked now many times on calls about how you expect this could become the first-line drug of choice among patients over time. you've talked now many times on calls about how you expect this could become the first-line drug of choice among patients over time

Speaker 2: Yes. I would say that, the short answer is efficacy, which is very, very strong. Though it's hard to do cross trial comparisons, the efficacy is better. Second is durability that we observed in gendered response rates only improving through the course of the first calendar year of therapy. I'd say third is convenience. Patients don't wanna experience their disease. They also don't wanna be reminded of their disease treating themselves. This medicine's given every six months after the loading dose, which is quite remarkable. Fourth is it targets the actual causal biology. Myasthenia gravis is fundamentally driven by autoreactive antibodies produced by a group of cells, B cells and pre-B cells, and UPLIZNA targeting CD19 works to deplete exactly those cells. A broader group of cells than, say, a CD20 monoclonal antibody that has that limited utility here. Yes. yes I would say that, the short answer is efficacy, which is very, very strong. i would say that the short answer is efficacy which is very very strong Though it's hard to do cross trial comparisons, the efficacy is better. though it's hard to do cross trial comparisons the efficacy is better Second is durability that we observed in gendered response rates only improving through the course of the first calendar year of therapy. second is durability that we observed in gendered response rates only improving through the course of the first calendar year of therapy I'd say third is convenience. i'd say third is convenience Patients don't wanna experience their disease. patients don't wanna experience their disease They also don't wanna be reminded of their disease treating themselves. they also don't wanna be reminded of their disease treating themselves This medicine's given every six months after the loading dose, which is quite remarkable. this medicine's given every six months after the loading dose which is quite remarkable Fourth is it targets the actual causal biology. fourth is it targets the actual causal biology Myasthenia gravis is fundamentally driven by autoreactive antibodies produced by a group of cells, B cells and pre-B cells, and UPLIZNA targeting CD19 works to deplete exactly those cells. myasthenia gravis is fundamentally driven by autoreactive antibodies produced by a group of cells b cells and pre-b cells and uplizna targeting cd19 works to deplete exactly those cells A broader group of cells than, say, a CD20 monoclonal antibody that has that limited utility here. a broader group of cells than say a cd20 monoclonal antibody that has that limited utility here I think that these four really important features, I mean, any one of them could be strong enough to compel a physician to prescribe. All four of these, including the fact that to date, the medicine's been rather well-tolerated, that's big for these patients. I think that we're not surprised, but we're delighted to see the increased uptake and interest and utility of UPLIZNA. After neuromyelitis optica spectrum disorder, after IgG4-related disease, you know, after generalized myasthenia gravis, the pattern that we're observing is that diseases driven by autoreactive antibodies should respond to UPLIZNA. If you look at that list in ChatGPT or your favorite medical textbook like Harrison's, that's a long list of diseases that we're prioritizing and sequentially just line 'em up and knock 'em down. I think that these four really important features, I mean, any one of them could be strong enough to compel a physician to prescribe. i think that these four really important features i mean any one of them could be strong enough to compel a physician to prescribe All four of these, including the fact that to date, the medicine's been rather well-tolerated, that's big for these patients. all four of these including the fact that to date the medicine's been rather well-tolerated that's big for these patients I think that we're not surprised, but we're delighted to see the increased uptake and interest and utility of UPLIZNA. i think that we're not surprised but we're delighted to see the increased uptake and interest and utility of uplizna After neuromyelitis optica spectrum disorder, after IgG4-related disease, you know, after generalized myasthenia gravis, the pattern that we're observing is that diseases driven by autoreactive antibodies should respond to UPLIZNA. after neuromyelitis optica spectrum disorder after igg4-related disease you know after generalized myasthenia gravis the pattern that we're observing is that diseases driven by autoreactive antibodies should respond to uplizna If you look at that list in ChatGPT or your favorite medical textbook like Harrison's, that's a long list of diseases that we're prioritizing and sequentially just line 'em up and knock 'em down. if you look at that list in chatgpt or your favorite medical textbook like harrison's that's a long list of diseases that we're prioritizing and sequentially just line 'em up and knock 'em down The next two for UPLIZNA will be autoimmune hepatitis and CIDP. The next two for UPLIZNA will be autoimmune hepatitis and CIDP. the next two for uplizna will be autoimmune hepatitis and cidp

Speaker 4: Okay. Let's stick to GMG for one more minute. Where are you seeing the early patient pickups coming from? Are they switch patients? What are they switching from? What percent of the usage right now is in treatment naive? Okay. okay Let's stick to GMG for one more minute. let's stick to gmg for one more minute Where are you seeing the early patient pickups coming from? where are you seeing the early patient pickups coming from Are they switch patients? are they switch patients What are they switching from? what are they switching from What percent of the usage right now is in treatment naive? what percent of the usage right now is in treatment naive

Speaker 2: Thanks. I'll leave it to Casey to discuss the specifics, but we're seeing uptake in both biologically experienced and biologically naive patients. Thanks. thanks I'll leave it to Casey to discuss the specifics, but we're seeing uptake in both biologically experienced and biologically naive patients. i'll leave it to casey to discuss the specifics but we're seeing uptake in both biologically experienced and biologically naive patients

Speaker 1: It's roughly a 50/50 split between those two groups at this point. Tazeen, it's a little bit early to be characterizing exactly what therapies individuals are switching to, but as you can imagine, with other therapies that are treated on a more frequent basis, every time they're in their physician's office is an opportunity to switch to UPLIZNA as well. Patients are looking for exactly the attributes that Jay described. It's roughly a 50/50 split between those two groups at this point. it's roughly a 50/50 split between those two groups at this point Tazeen, it's a little bit early to be characterizing exactly what therapies individuals are switching to, but as you can imagine, with other therapies that are treated on a more frequent basis, every time they're in their physician's office is an opportunity to switch to UPLIZNA as well. tazeen it's a little bit early to be characterizing exactly what therapies individuals are switching to but as you can imagine with other therapies that are treated on a more frequent basis every time they're in their physician's office is an opportunity to switch to uplizna as well Patients are looking for exactly the attributes that Jay described. patients are looking for exactly the attributes that jay described

Speaker 4: Okay. On the one that you're pursuing, one of the two that you're pursuing next, CIDP, also one that's been dominated by FcRNs, you also have IVIG as a indicated usage drug. How are you thinking about the dynamics of that market versus what you're seeing so far with GMG? Okay. okay On the one that you're pursuing, one of the two that you're pursuing next, CIDP, also one that's been dominated by FcRNs, you also have IVIG as a indicated usage drug. on the one that you're pursuing one of the two that you're pursuing next cidp also one that's been dominated by fcrns you also have ivig as a indicated usage drug How are you thinking about the dynamics of that market versus what you're seeing so far with GMG? how are you thinking about the dynamics of that market versus what you're seeing so far with gmg

Speaker 2: I'd say more similar than different. I mean, the medicine has to work there, but it targets, again, the underlying biology. It meets the patient where they're at with a convenient dosing schema. I should hope that if active, the durability would be another strong feature, given the pharmacodynamic suppression of CD19 positive B cells is so durable with this afucosylated monoclonal antibody. I would say, you know, provided strong efficacy, which is really the anchor of why this medicine is so desirable in myasthenia gravis, generalized myasthenia gravis, you know, I think in CIDP it stands to be very much the same story. I'd say more similar than different. i'd say more similar than different I mean, the medicine has to work there, but it targets, again, the underlying biology. i mean the medicine has to work there but it targets again the underlying biology It meets the patient where they're at with a convenient dosing schema. it meets the patient where they're at with a convenient dosing schema I should hope that if active, the durability would be another strong feature, given the pharmacodynamic suppression of CD19 positive B cells is so durable with this afucosylated monoclonal antibody. i should hope that if active the durability would be another strong feature given the pharmacodynamic suppression of cd19 positive b cells is so durable with this afucosylated monoclonal antibody I would say, you know, provided strong efficacy, which is really the anchor of why this medicine is so desirable in myasthenia gravis, generalized myasthenia gravis, you know, I think in CIDP it stands to be very much the same story. i would say you know provided strong efficacy which is really the anchor of why this medicine is so desirable in myasthenia gravis generalized myasthenia gravis you know i think in cidp it stands to be very much the same story

Speaker 4: When should we expect to see data on that? When should we expect to see data on that? when should we expect to see data on that

Speaker 2: We haven't as yet indicated when that study will read out. We haven't as yet indicated when that study will read out. we haven't as yet indicated when that study will read out

Speaker 1: Yeah, we'll be starting those two phase III studies later this year. Yeah, we'll be starting those two phase III studies later this year. yeah we'll be starting those two phase iii studies later this year

Speaker 4: Okay. Are those the extent of indications that you'd wanna pursue for UPLIZNA, or are there others behind it? Okay. okay Are those the extent of indications that you'd wanna pursue for UPLIZNA, or are there others behind it? are those the extent of indications that you'd wanna pursue for uplizna or are there others behind it

Speaker 2: No, there are additional indications for UPLIZNA, and I would also share that because we've been in CD19 for so long, and you must know we have an FDA-approved and broadly utilized standard of care frontline acute lymphoblastic leukemia CD19 called blinatumomab, BLINCYTO for its leukemia use case and intravenous continuous infusion, that in our fridges and in our labs, we have a number of molecules targeting this target and this pathway, and have built a whole program around B-cell depletion leveraging CD19. Some of those diseases will track very nicely to an UPLIZNA use case, and others will use a pipeline agent. I would expect to see, you know, proof of concept, if not additional data, in lupus with and without nephritis and other disease states. No, there are additional indications for UPLIZNA, and I would also share that because we've been in CD19 for so long, and you must know we have an FDA-approved and broadly utilized standard of care frontline acute lymphoblastic leukemia CD19 called blinatumomab, BLINCYTO for its leukemia use case and intravenous continuous infusion, that in our fridges and in our labs, we have a number of molecules targeting this target and this pathway, and have built a whole program around B-cell depletion leveraging CD19. no there are additional indications for uplizna and i would also share that because we've been in cd19 for so long and you must know we have an fda-approved and broadly utilized standard of care frontline acute lymphoblastic leukemia cd19 called blinatumomab blincyto for its leukemia use case and intravenous continuous infusion that in our fridges and in our labs we have a number of molecules targeting this target and this pathway and have built a whole program around b-cell depletion leveraging cd19 Some of those diseases will track very nicely to an UPLIZNA use case, and others will use a pipeline agent. some of those diseases will track very nicely to an uplizna use case and others will use a pipeline agent I would expect to see, you know, proof of concept, if not additional data, in lupus with and without nephritis and other disease states. i would expect to see you know proof of concept if not additional data in lupus with and without nephritis and other disease states

Speaker 4: Okay. Okay. okay

Speaker 2: Yeah. Yeah. yeah

Speaker 4: All right. Now let's move on to some of your pipeline assets. Let's start with MariTide. There seems to be a bifurcated reaction to this drug. It's either this is great, it's going to be a market share leader in the obesity space, or, well, there's not enough data right now for us to kind of know where it's going to land. What is the real differentiation? You've got a mechanism, GLP, but it's going to be dosed less frequently. How is that going to compare to a multitude of other companies that might hope to launch around the same time as you guys would? Maybe help the market better understand this drug. Mechanistically, why do you think it could have some advantages over just being another GLP on the market? All right. all right Now let's move on to some of your pipeline assets. now let's move on to some of your pipeline assets Let's start with MariTide. let's start with maritide There seems to be a bifurcated reaction to this drug. there seems to be a bifurcated reaction to this drug It's either this is great, it's going to be a market share leader in the obesity space, or, well, there's not enough data right now for us to kind of know where it's going to land. it's either this is great it's going to be a market share leader in the obesity space or well there's not enough data right now for us to kind of know where it's going to land What is the real differentiation? what is the real differentiation You've got a mechanism, GLP, but it's going to be dosed less frequently. you've got a mechanism glp but it's going to be dosed less frequently How is that going to compare to a multitude of other companies that might hope to launch around the same time as you guys would? how is that going to compare to a multitude of other companies that might hope to launch around the same time as you guys would Maybe help the market better understand this drug. maybe help the market better understand this drug Mechanistically, why do you think it could have some advantages over just being another GLP on the market? mechanistically why do you think it could have some advantages over just being another glp on the market

Speaker 2: Thank you. Well, I would start by saying that MariTide is a very special molecule, and it's not that complicated. It's a GIP antagonist antibody with GLP-1 agonist peptides that has dramatic efficacy on weight loss, is extremely well tolerated at target doses, that benefits from dose escalation just like all the other ones, and it's given less frequently. I don't think we should overcomplicate it. It's very simple. If GLP-1 peptides were twice a day, they'd be less exciting than every week. Thank you. thank you Well, I would start by saying that MariTide is a very special molecule, and it's not that complicated. It's a GIP antagonist antibody with GLP-1 agonist peptides that has dramatic efficacy on weight loss, is extremely well tolerated at target doses, that benefits from dose escalation just like all the other ones, and it's given less frequently. well i would start by saying that maritide is a very special molecule and it's not that complicated. it's a gip antagonist antibody with glp-1 agonist peptides that has dramatic efficacy on weight loss is extremely well tolerated at target doses that benefits from dose escalation just like all the other ones and it's given less frequently I don't think we should overcomplicate it. i don't think we should overcomplicate it It's very simple. it's very simple If GLP-1 peptides were twice a day, they'd be less exciting than every week. if glp-1 peptides were twice a day they'd be less exciting than every week If a medicine that exploits this mechanism can be given monthly or as Peter shared, maybe every eight weeks, where we've already shown and presented data demonstrating real efficacy, maybe every 12 weeks, as we've indicated, we've some maintenance data that gives us some conviction there, and we continue to study every eight and every 12 weeks in prospective and now phase III trials. I wouldn't overcomplicate it. It's a very active incretin-based weight loss medicine that is just given less frequently. That's very special. The antibody core affords an opportunity for patients not to inject themselves every single week. As we continue to see in real-world evidence, weekly injectables are challenging for patients to stay on. If a medicine that exploits this mechanism can be given monthly or as Peter shared, maybe every eight weeks, where we've already shown and presented data demonstrating real efficacy, maybe every 12 weeks, as we've indicated, we've some maintenance data that gives us some conviction there, and we continue to study every eight and every 12 weeks in prospective and now phase III trials. if a medicine that exploits this mechanism can be given monthly or as peter shared maybe every eight weeks where we've already shown and presented data demonstrating real efficacy maybe every 12 weeks as we've indicated we've some maintenance data that gives us some conviction there and we continue to study every eight and every 12 weeks in prospective and now phase iii trials I wouldn't overcomplicate it. i wouldn't overcomplicate it It's a very active incretin-based weight loss medicine that is just given less frequently. it's a very active incretin-based weight loss medicine that is just given less frequently That's very special. that's very special The antibody core affords an opportunity for patients not to inject themselves every single week. the antibody core affords an opportunity for patients not to inject themselves every single week As we continue to see in real-world evidence, weekly injectables are challenging for patients to stay on. as we continue to see in real-world evidence weekly injectables are challenging for patients to stay on If half of patients are stopping the use of these medicines at six months or 12 months, are the patients getting what they need, the protection for these serious diseases? Are the payers getting what they deserve for providing access to these medicines? You know, the features of MariTide could improve patient persistence, and for chronic diseases, that really matters. I wouldn't overcomplicate it, an incretin-based medicine that is given less frequently. If half of patients are stopping the use of these medicines at six months or 12 months, are the patients getting what they need, the protection for these serious diseases? if half of patients are stopping the use of these medicines at six months or 12 months are the patients getting what they need the protection for these serious diseases Are the payers getting what they deserve for providing access to these medicines? are the payers getting what they deserve for providing access to these medicines You know, the features of MariTide could improve patient persistence, and for chronic diseases, that really matters. you know the features of maritide could improve patient persistence and for chronic diseases that really matters I wouldn't overcomplicate it, an incretin-based medicine that is given less frequently. i wouldn't overcomplicate it an incretin-based medicine that is given less frequently

Speaker 4: Okay. Okay. okay

Speaker 3: As said by a CFO. As said by a CFO. as said by a cfo

Speaker 4: As simple as it gets. As simple as it gets. as simple as it gets

Speaker 3: Tazeen Ahmad, think 52, 12, 6, 4. Which one of those do you want if you're getting poked? Tazeen Ahmad, think 52, 12, 6, 4. tazeen ahmad think 52 12 6 4 Which one of those do you want if you're getting poked? which one of those do you want if you're getting poked

Speaker 2: Yeah, it's a fair point. When I got my flu shot, I didn't ask if it could be weekly, you know? Let's see how the data appears when we read out these phase III studies, but we are very confident in the profile of this medicine, the design of these trials. Their execution has gone very well, I wouldn't overcomplicate it. Yeah, it's a fair point. yeah it's a fair point When I got my flu shot, I didn't ask if it could be weekly, you know? when i got my flu shot i didn't ask if it could be weekly you know Let's see how the data appears when we read out these phase III studies, but we are very confident in the profile of this medicine, the design of these trials. let's see how the data appears when we read out these phase iii studies but we are very confident in the profile of this medicine the design of these trials Their execution has gone very well, I wouldn't overcomplicate it. their execution has gone very well i wouldn't overcomplicate it

Speaker 4: Okay. Okay. okay

Speaker 2: Yeah. Yeah. yeah

Speaker 4: What about the tolerability profile? I think there's been some questions about it. You're looking at various titrations, Govada. Anything you could share on that front? What about the tolerability profile? what about the tolerability profile I think there's been some questions about it. i think there's been some questions about it You're looking at various titrations, Govada. you're looking at various titrations govada Anything you could share on that front? anything you could share on that front

Speaker 2: Yeah. I'd break tolerability into two conversations. One is tolerability at target dose. It's extremely well tolerated at target dose. You could be on 350 mg of this. You could get it every single month. As we've shown with the Manhattan plots from phase II, the drug is just innocuous, just very well tolerated by patients. The reason for this is it's an antibody core, so you're just kind of marinating in it. It's just smooth exposure. When you do a pill or a weekly injectable, there's a spike. A medicine is absorbed, and then it's metabolized. Absorbed, and then it's metabolized. The part of the brain that experiences nausea and vomiting is called the area postrema in the hypothalamus, and it responds to these jolts. Yeah. yeah I'd break tolerability into two conversations. i'd break tolerability into two conversations One is tolerability at target dose. one is tolerability at target dose It's extremely well tolerated at target dose. it's extremely well tolerated at target dose You could be on 350 mg of this. you could be on 350 mg of this You could get it every single month. you could get it every single month As we've shown with the Manhattan plots from phase II, the drug is just innocuous, just very well tolerated by patients. as we've shown with the manhattan plots from phase ii the drug is just innocuous just very well tolerated by patients The reason for this is it's an antibody core, so you're just kind of marinating in it. the reason for this is it's an antibody core so you're just kind of marinating in it It's just smooth exposure. it's just smooth exposure When you do a pill or a weekly injectable, there's a spike. when you do a pill or a weekly injectable there's a spike A medicine is absorbed, and then it's metabolized. a medicine is absorbed and then it's metabolized Absorbed, and then it's metabolized. absorbed and then it's metabolized The part of the brain that experiences nausea and vomiting is called the area postrema in the hypothalamus, and it responds to these jolts. the part of the brain that experiences nausea and vomiting is called the area postrema in the hypothalamus and it responds to these jolts If we see, let's say, the data from oral GLP-1s as presented to date, and you look at their Manhattan plots, which is how symptoms are tracked over time, there's just a scattering persistence of nausea and vomiting. I think some data was even disclosed today about switching from injectables to orals, and there was real associated, almost 19% nausea and significant vomiting moving to more frequent dosing. If we see, let's say, the data from oral GLP-1s as presented to date, and you look at their Manhattan plots, which is how symptoms are tracked over time, there's just a scattering persistence of nausea and vomiting. if we see let's say the data from oral glp-1s as presented to date and you look at their manhattan plots which is how symptoms are tracked over time there's just a scattering persistence of nausea and vomiting I think some data was even disclosed today about switching from injectables to orals, and there was real associated, almost 19% nausea and significant vomiting moving to more frequent dosing. i think some data was even disclosed today about switching from injectables to orals and there was real associated almost 19% nausea and significant vomiting moving to more frequent dosing MariTide at target dose is just smooth exposure and a smooth experience. Upfront treatment. Here, MariTide is more similar than different to other injectables, that to get a GLP-1 medicine on board, you need to start low and go slow with dose titration. We've learned, as every other company has, prosecuting this mechanism, that no dose escalation is worse than 1-step, that 2-step is better than 1-step, and as we shared on our earnings call, that 3-step is unsurprisingly better than 2-step. We employ 3-step dose escalation in our phase III studies, and have real confidence that the upfront experience with MariTide will be competitive and the on-treatment experience will be extraordinary. MariTide at target dose is just smooth exposure and a smooth experience. maritide at target dose is just smooth exposure and a smooth experience Upfront treatment. upfront treatment Here, MariTide is more similar than different to other injectables, that to get a GLP-1 medicine on board, you need to start low and go slow with dose titration. here maritide is more similar than different to other injectables that to get a glp-1 medicine on board you need to start low and go slow with dose titration We've learned, as every other company has, prosecuting this mechanism, that no dose escalation is worse than 1-step, that 2-step is better than 1-step, and as we shared on our earnings call, that 3-step is unsurprisingly better than 2-step. we've learned as every other company has prosecuting this mechanism that no dose escalation is worse than 1-step that 2-step is better than 1-step and as we shared on our earnings call that 3-step is unsurprisingly better than 2-step We employ 3-step dose escalation in our phase III studies, and have real confidence that the upfront experience with MariTide will be competitive and the on-treatment experience will be extraordinary. we employ 3-step dose escalation in our phase iii studies and have real confidence that the upfront experience with maritide will be competitive and the on-treatment experience will be extraordinary

Speaker 4: Okay. Let's talk about the opportunity for it to be used in a maintenance setting. Okay. okay Let's talk about the opportunity for it to be used in a maintenance setting. let's talk about the opportunity for it to be used in a maintenance setting

Speaker 2: Yeah. You know, none of these diseases go away after 52 or 72 weeks, which is how we're studying these medicines in clinical investigation. In this room and rooms like it, those numbers matter, and we're gonna deliver great numbers. In clinical practice, these physicians are seeing patients, and these patients are experiencing these diseases for a whole lifetime. Yeah. yeah You know, none of these diseases go away after 52 or 72 weeks, which is how we're studying these medicines in clinical investigation. you know none of these diseases go away after 52 or 72 weeks which is how we're studying these medicines in clinical investigation In this room and rooms like it, those numbers matter, and we're gonna deliver great numbers. in this room and rooms like it those numbers matter and we're gonna deliver great numbers In clinical practice, these physicians are seeing patients, and these patients are experiencing these diseases for a whole lifetime. in clinical practice these physicians are seeing patients and these patients are experiencing these diseases for a whole lifetime How patients can remain on therapy and derive durable benefit for their whole lifetime, because we're not curing obesity with these medicines, but we are effectively treating it. We are effectively treating associated diabetes and many other related conditions. We and others have become very interested for what happens after the primary endpoint. Through long-term extensions and now dedicated phase III clinical investigation, we intend to characterize the benefits of MariTide when used for an additional year after a year of treatment or beyond. There, we believe that one might even require less MariTide than the acute and treatment phase because the long-lasting antibody has long-lasting effects. We've seen data in phase II clinical investigation in our part II extension, that every eight-week and even every 12-week dosing can maintain lost weight. How patients can remain on therapy and derive durable benefit for their whole lifetime, because we're not curing obesity with these medicines, but we are effectively treating it. how patients can remain on therapy and derive durable benefit for their whole lifetime because we're not curing obesity with these medicines but we are effectively treating it We are effectively treating associated diabetes and many other related conditions. we are effectively treating associated diabetes and many other related conditions We and others have become very interested for what happens after the primary endpoint. we and others have become very interested for what happens after the primary endpoint Through long-term extensions and now dedicated phase III clinical investigation, we intend to characterize the benefits of MariTide when used for an additional year after a year of treatment or beyond. through long-term extensions and now dedicated phase iii clinical investigation we intend to characterize the benefits of maritide when used for an additional year after a year of treatment or beyond There, we believe that one might even require less MariTide than the acute and treatment phase because the long-lasting antibody has long-lasting effects. there we believe that one might even require less maritide than the acute and treatment phase because the long-lasting antibody has long-lasting effects We've seen data in phase II clinical investigation in our part II extension, that every eight-week and even every 12-week dosing can maintain lost weight. we've seen data in phase ii clinical investigation in our part ii extension that every eight-week and even every 12-week dosing can maintain lost weight The field of obesity is not surprised by this because they've talked about this metabolic set point for a long, long time, and these medicines are reducing that set point and then keeping the weight off. We now want to follow up on this strong signal in two ways. One is could maintenance MariTide be less frequent than treatment MariTide? Second, if we can switch from MariTide to a less frequent MariTide, could we get people off weekly injectables to a much more convenient maintenance MariTide? We announced at our earnings call that we're initiating clinical investigation on a maintenance as well as on a switching to MariTide experience that will feature less frequent dosing. The field of obesity is not surprised by this because they've talked about this metabolic set point for a long, long time, and these medicines are reducing that set point and then keeping the weight off. the field of obesity is not surprised by this because they've talked about this metabolic set point for a long long time and these medicines are reducing that set point and then keeping the weight off We now want to follow up on this strong signal in two ways. we now want to follow up on this strong signal in two ways One is could maintenance MariTide be less frequent than treatment MariTide? one is could maintenance maritide be less frequent than treatment maritide Second, if we can switch from MariTide to a less frequent MariTide, could we get people off weekly injectables to a much more convenient maintenance MariTide? second if we can switch from maritide to a less frequent maritide could we get people off weekly injectables to a much more convenient maintenance maritide We announced at our earnings call that we're initiating clinical investigation on a maintenance as well as on a switching to MariTide experience that will feature less frequent dosing. we announced at our earnings call that we're initiating clinical investigation on a maintenance as well as on a switching to maritide experience that will feature less frequent dosing This is very important to translate efficacy, which is what you see on a clinical trial, to effectiveness, how well medicines can work in the real world. This is very important to translate efficacy, which is what you see on a clinical trial, to effectiveness, how well medicines can work in the real world. this is very important to translate efficacy which is what you see on a clinical trial to effectiveness how well medicines can work in the real world

Speaker 4: Okay. Thanks for all that color. How long do you expect this maintenance study that you announced to last? Okay. okay Thanks for all that color. thanks for all that color How long do you expect this maintenance study that you announced to last? how long do you expect this maintenance study that you announced to last

Speaker 2: Well, we have I think reported on clinicaltrials.gov the length of the maintenance studies, and they'll be about a calendar year. Well, we have I think reported on clinicaltrials.gov the length of the maintenance studies, and they'll be about a calendar year. well we have i think reported on clinicaltrials.gov the length of the maintenance studies and they'll be about a calendar year

Speaker 4: Okay. In terms of pace of enrollment, do you think that this is gonna be quickly enrolled? Okay. okay In terms of pace of enrollment, do you think that this is gonna be quickly enrolled? in terms of pace of enrollment do you think that this is gonna be quickly enrolled

Speaker 2: You know, the long-term extensions are invitations to patients who've been on the phase III clinical trial to continue. There we expect real followership, really strong participation. When we did our phase II clinical study and we offered patients to complete onto a maintenance, I think we had more than 90% conversion. You know, the long-term extensions are invitations to patients who've been on the phase III clinical trial to continue. you know the long-term extensions are invitations to patients who've been on the phase iii clinical trial to continue There we expect real followership, really strong participation. there we expect real followership really strong participation When we did our phase II clinical study and we offered patients to complete onto a maintenance, I think we had more than 90% conversion. when we did our phase ii clinical study and we offered patients to complete onto a maintenance i think we had more than 90% conversion Is that right, Casey? Is that right, Casey? is that right casey

Speaker 1: That's correct. That's correct. that's correct

Speaker 2: Yeah, more than 90% participation. You get an email or your doctor or clinician asks you, "Could you be interested to keep taking this medicine for a year?" More than 90% signed up for that, which is people voting with their feet and their thumbs. We're expecting very strong participation. In fact, all of our clinical studies of MariTide have enrolled ahead of expectations. These are a strong set of clinical trials. Yeah, more than 90% participation. yeah more than 90% participation You get an email or your doctor or clinician asks you, "Could you be interested to keep taking this medicine for a year?" More than 90% signed up for that, which is people voting with their feet and their thumbs. you get an email or your doctor or clinician asks you "could you be interested to keep taking this medicine for a year?" more than 90% signed up for that which is people voting with their feet and their thumbs We're expecting very strong participation. we're expecting very strong participation In fact, all of our clinical studies of MariTide have enrolled ahead of expectations. in fact all of our clinical studies of maritide have enrolled ahead of expectations These are a strong set of clinical trials. these are a strong set of clinical trials

Speaker 4: We'll stay tuned on updates from these studies as we go forward. Let's maybe take a minute to talk about a couple of other pipeline assets and indications. I wanted to maybe spend a little bit of time on Lp(a) because. We'll stay tuned on updates from these studies as we go forward. we'll stay tuned on updates from these studies as we go forward Let's maybe take a minute to talk about a couple of other pipeline assets and indications. let's maybe take a minute to talk about a couple of other pipeline assets and indications I wanted to maybe spend a little bit of time on Lp(a) because. i wanted to maybe spend a little bit of time on lp(a) because

Speaker 2: Yeah. Yeah. yeah

Speaker 4: You've got a competitor that's gonna have data coming, I think, later this year, for which nearly everyone expects there to be a read-through for Amgen. Rather than me talking to investors about what the right read-through should be, I thought I would ask you, Jay. What is the right read-through to be thinking about when we see the Novartis data released? You've got a competitor that's gonna have data coming, I think, later this year, for which nearly everyone expects there to be a read-through for Amgen. you've got a competitor that's gonna have data coming i think later this year for which nearly everyone expects there to be a read-through for amgen Rather than me talking to investors about what the right read-through should be, I thought I would ask you, Jay. rather than me talking to investors about what the right read-through should be i thought i would ask you jay What is the right read-through to be thinking about when we see the Novartis data released? what is the right read-through to be thinking about when we see the novartis data released

Speaker 2: Yes. Yes. yes

Speaker 4: For Lp(a) later this year? For Lp(a) later this year? for lp(a) later this year

Speaker 2: No, know that medicine well, and I'm following that research very closely as are, as is this community. I would say that the read-through from the Novartis readout midyear will be sort of directional, but not absolute as to what to expect from our OCEAN(a) study. No, know that medicine well, and I'm following that research very closely as are, as is this community. no know that medicine well and i'm following that research very closely as are as is this community I would say that the read-through from the Novartis readout midyear will be sort of directional, but not absolute as to what to expect from our OCEAN(a) study. i would say that the read-through from the novartis readout midyear will be sort of directional but not absolute as to what to expect from our ocean(a) study That is forecast to read out later. It's event-driven study. The reason for that is that, number one, we're both testing a really strong hypothesis with very effective medicines. Lp(a), a genetically defined risk factor for atherosclerotic cardiovascular disease, each Lp(a) particle is 6x more atherogenic pound for pound than an LDL-C particle. Look at all that we know about LDL-C and its reduction and its management. Experiments of nature have shown that a gradient, that as Lp(a) ramps up in our bloodstreams, our risk for heart disease ramps up in parallel. Both of these companies are testing the same hypothesis. I like our chances. Our medicine is quite a bit more potent than the Novartis medicine. If that medicine, pelacarsen, reduces Lp(a) 70%-75%, our medicine, olpasiran, flatlines Lp(a) more than 95%. That is forecast to read out later. that is forecast to read out later It's event-driven study. it's event-driven study The reason for that is that, number one, we're both testing a really strong hypothesis with very effective medicines. the reason for that is that number one we're both testing a really strong hypothesis with very effective medicines Lp(a), a genetically defined risk factor for atherosclerotic cardiovascular disease, each Lp(a) particle is 6x more atherogenic pound for pound than an LDL-C particle. lp(a) a genetically defined risk factor for atherosclerotic cardiovascular disease each lp(a) particle is 6x more atherogenic pound for pound than an ldl-c particle Look at all that we know about LDL-C and its reduction and its management. look at all that we know about ldl-c and its reduction and its management Experiments of nature have shown that a gradient, that as Lp(a) ramps up in our bloodstreams, our risk for heart disease ramps up in parallel. experiments of nature have shown that a gradient that as lp(a) ramps up in our bloodstreams our risk for heart disease ramps up in parallel Both of these companies are testing the same hypothesis. both of these companies are testing the same hypothesis I like our chances. i like our chances Our medicine is quite a bit more potent than the Novartis medicine. our medicine is quite a bit more potent than the novartis medicine If that medicine, pelacarsen, reduces Lp(a) 70%-75%, our medicine, olpasiran, flatlines Lp(a) more than 95%. if that medicine pelacarsen reduces lp(a) 70%-75% our medicine olpasiran flatlines lp(a) more than 95% Could matter. Second is, our study has a slightly different endpoint. Could matter. could matter Second is, our study has a slightly different endpoint. second is our study has a slightly different endpoint Novartis uses a 4-point MACE endpoint, major adverse cardiovascular events. We're using a 3-point endpoint. We didn't see, from an epidemiologic standpoint, quite as much weight around stroke, and so we've thought to consolidate all of our alpha around the endpoints that we think will really move the needle for patients. In that regard, it Novartis is a good company with a good molecule, asking a good question, and so we're very interested to see the outcome. The guidance we think would be for us, would be directional. Novartis uses a 4-point MACE endpoint, major adverse cardiovascular events. novartis uses a 4-point mace endpoint major adverse cardiovascular events We're using a 3-point endpoint. we're using a 3-point endpoint We didn't see, from an epidemiologic standpoint, quite as much weight around stroke, and so we've thought to consolidate all of our alpha around the endpoints that we think will really move the needle for patients. we didn't see from an epidemiologic standpoint quite as much weight around stroke and so we've thought to consolidate all of our alpha around the endpoints that we think will really move the needle for patients In that regard, it Novartis is a good company with a good molecule, asking a good question, and so we're very interested to see the outcome. in that regard it novartis is a good company with a good molecule asking a good question and so we're very interested to see the outcome The guidance we think would be for us, would be directional. the guidance we think would be for us would be directional

Speaker 4: Okay. Okay. okay

Speaker 2: Yeah. Yeah. yeah

Speaker 4: When the data does come out, you know, does that allow you to make any changes if you need to? Would you think you would want to? When the data does come out, you know, does that allow you to make any changes if you need to? when the data does come out you know does that allow you to make any changes if you need to Would you think you would want to? would you think you would want to

Speaker 2: You know, I think a late-stage protocol amendment would not be our preferred path forward. We are very confident in the design of this trial. You know, I think a late-stage protocol amendment would not be our preferred path forward. you know i think a late-stage protocol amendment would not be our preferred path forward We are very confident in the design of this trial. we are very confident in the design of this trial

Speaker 4: It's an event-driven study. It's an event-driven study. it's an event-driven study

Speaker 2: Yeah. Yeah. yeah

Speaker 4: I think some folks had expected maybe it could come out later this year, but now I think expectations are some time into next year. When would you have a better sense of guiding towards a data readout? I think some folks had expected maybe it could come out later this year, but now I think expectations are some time into next year. i think some folks had expected maybe it could come out later this year but now i think expectations are some time into next year When would you have a better sense of guiding towards a data readout? when would you have a better sense of guiding towards a data readout

Speaker 2: You know, we, there's a monitoring committee that's tracking these events. We're performing this study in collaboration with the leading global cardiovascular group. We and they have executed through the development of Repatha cardiovascular outcome trials in a very expert way. We are forecasting it's, the event rate is not gonna read out this year, and we'll have more to say about the readout as the aperture narrows on the target date that, which is a certain number of events. You know, we, there's a monitoring committee that's tracking these events. you know we there's a monitoring committee that's tracking these events We're performing this study in collaboration with the leading global cardiovascular group. we're performing this study in collaboration with the leading global cardiovascular group We and they have executed through the development of Repatha cardiovascular outcome trials in a very expert way. we and they have executed through the development of repatha cardiovascular outcome trials in a very expert way We are forecasting it's, the event rate is not gonna read out this year, and we'll have more to say about the readout as the aperture narrows on the target date that, which is a certain number of events. we are forecasting it's the event rate is not gonna read out this year and we'll have more to say about the readout as the aperture narrows on the target date that which is a certain number of events

Speaker 4: Okay. Maybe last question really quickly, how big do you think this opportunity is? Okay. okay Maybe last question really quickly, how big do you think this opportunity is? maybe last question really quickly how big do you think this opportunity is

Speaker 2: You know, one in five humans is born with an elevated Lp(a), and we are studying secondary prevention first. Should that be positive, as for LDL-C, I would have a hard time explaining scientifically why that mechanism wouldn't work in primary prevention, which is a much bigger number of people. It's a big opportunity. You know, one in five humans is born with an elevated Lp(a), and we are studying secondary prevention first. you know one in five humans is born with an elevated lp(a) and we are studying secondary prevention first Should that be positive, as for LDL-C, I would have a hard time explaining scientifically why that mechanism wouldn't work in primary prevention, which is a much bigger number of people. should that be positive as for ldl-c i would have a hard time explaining scientifically why that mechanism wouldn't work in primary prevention which is a much bigger number of people It's a big opportunity. it's a big opportunity

Speaker 4: Would you put it on the same level as, you know, LDL, like statins and those types of drugs, or bigger? Would you put it on the same level as, you know, LDL, like statins and those types of drugs, or bigger? would you put it on the same level as you know ldl like statins and those types of drugs or bigger

Speaker 2: It feels like that. you know, it feels like that, but, Casey, what would you say? It feels like that. you know, it feels like that, but, Casey, what would you say? it feels like that you know it feels like that but casey what would you say

Speaker 1: I'd say it would be dependent upon the phase III data. I'd say it would be dependent upon the phase III data. i'd say it would be dependent upon the phase iii data

Speaker 4: Of course. Of course. of course

Speaker 2: Well said. Well said. well said

Speaker 4: I guess if you needed to build a sales force for that, what kind of investment would you need? I guess if you needed to build a sales force for that, what kind of investment would you need? i guess if you needed to build a sales force for that what kind of investment would you need

Speaker 1: I would say, and it's a good point, if you think about Repatha and what Peter described in terms of our cardiometabolic foundation that we built, very strong cardiology presence, very strong primary care presence. You can layer in olpasiran on top of that, and then also think about MariTide and the various metabolic diseases that we're studying with MariTide, would also fit right in. We feel like we have the potential to have a very strong cardiometabolic presence in general, especially if we're successful with MariTide and with olpasiran on top of what we built with Repatha. I would say, and it's a good point, if you think about Repatha and what Peter described in terms of our cardiometabolic foundation that we built, very strong cardiology presence, very strong primary care presence. i would say and it's a good point if you think about repatha and what peter described in terms of our cardiometabolic foundation that we built very strong cardiology presence very strong primary care presence You can layer in olpasiran on top of that, and then also think about MariTide and the various metabolic diseases that we're studying with MariTide, would also fit right in. you can layer in olpasiran on top of that and then also think about maritide and the various metabolic diseases that we're studying with maritide would also fit right in We feel like we have the potential to have a very strong cardiometabolic presence in general, especially if we're successful with MariTide and with olpasiran on top of what we built with Repatha. we feel like we have the potential to have a very strong cardiometabolic presence in general especially if we're successful with maritide and with olpasiran on top of what we built with repatha

Speaker 4: Yeah, actually you bring up a good point. What type of overlap would there be in physicians prescribing Repatha and who might prescribe it for Lp(a)? Yeah, actually you bring up a good point. yeah actually you bring up a good point What type of overlap would there be in physicians prescribing Repatha and who might prescribe it for Lp(a)? what type of overlap would there be in physicians prescribing repatha and who might prescribe it for lp(a)

Speaker 2: It would be a high degree of overlap. Lipid management clinics are now measuring Lp(a), and the current guidelines from the AHA, one thing they got just absolutely right was recommending that patients know their Lp(a) number, as all of us in this room should. Because even without effective medicines that we hope to have in the near term, knowing you have an elevated genetically defined risk that you can't eat better and it goes away, stop smoking, it goes away, even Repatha doesn't make it go away, you approach your life a little bit differently perhaps. Maybe you do an extra 15 minutes on the treadmill every morning. I think knowing about Lp(a) is very important, and in that way, the community's activated. It would be a high degree of overlap. it would be a high degree of overlap Lipid management clinics are now measuring Lp(a), and the current guidelines from the AHA, one thing they got just absolutely right was recommending that patients know their Lp(a) number, as all of us in this room should. lipid management clinics are now measuring lp(a) and the current guidelines from the aha one thing they got just absolutely right was recommending that patients know their lp(a) number as all of us in this room should Because even without effective medicines that we hope to have in the near term, knowing you have an elevated genetically defined risk that you can't eat better and it goes away, stop smoking, it goes away, even Repatha doesn't make it go away, you approach your life a little bit differently perhaps. because even without effective medicines that we hope to have in the near term knowing you have an elevated genetically defined risk that you can't eat better and it goes away stop smoking it goes away even repatha doesn't make it go away you approach your life a little bit differently perhaps Maybe you do an extra 15 minutes on the treadmill every morning. maybe you do an extra 15 minutes on the treadmill every morning I think knowing about Lp(a) is very important, and in that way, the community's activated. i think knowing about lp(a) is very important and in that way the community's activated Lp(a) measurement is in the guidelines, and that leads to the question, okay, so what can we do about it? Lp(a) measurement is in the guidelines, and that leads to the question, okay, so what can we do about it? lp(a) measurement is in the guidelines and that leads to the question okay so what can we do about it

Speaker 4: Okay. With that, we're out of time. Thanks, gentlemen, for joining me today. Okay. okay With that, we're out of time. with that we're out of time Thanks, gentlemen, for joining me today. thanks gentlemen for joining me today

Speaker 2: Thank- Thank- thank-

Speaker 4: Thanks, everyone, for listening. Thanks, everyone, for listening. thanks everyone for listening

Speaker 2: Thank you, Tazeen, and thank you, Bo. Thank you, Tazeen, and thank you, Bo. thank you tazeen and thank you bo